Dr. John Warrick

Associate Professor of Biology
Co-coordinator, Neuroscience Program

Profile

Drosophilia models to study human polyglutamine diseases. Secondary interests include the study of neurogenetic behavior in Drosophila, especially circadian rhythms and visually driven behaviors.

Awards

Jeffress Memorial Trust, "CREB-binding Protein Modulation in a Drosophila Model of MJD and the Role of Chaperones"

National Institutes of Health, “Finding polyglutamine disease and rescue mechanisms using proteomic analysis”

Presentations

HHMI Research Introduction, October 21, 2010.

Publications

Articles

Martin I., Jones M.A., Rhodenizer D., Zheng J., Warrick J.M., Seroude L., Grotewiel M. (2009) Sod2 knock-down in the musculature has whole organism consequences in Drosophila. Free Radic Biol Med;47(6):803-13.

Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Muller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wullner U, Frank R, Hartl UF, Bonini NM, Wanker EE. (2006). An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.  EMBO J.; 25(7):1547-58

Warrick, J.M., Gordesky-Gold, B., Morabito, L., Faust, L., Paulson, H.L., and Bonini, N.M. (2005). Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Mol Cell: 18, 37-48.

Chan, H.Y.E*. and Warrick, J.M.*, Andriola, I., and Merry, D., and Bonini, N.M.  (2002).  Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Human Molecular Genetics 11 (23):2895-2904.

Education

Ph.D., Temple University

B.S., King's College

Contact Information

B-212 Gottwald Center for the Sciences
(804) 289-8231
(Mobile)
(804) 289-8233 (Fax)

Areas of Expertise

Genetic and Molecular Basis of Neurodegenerative Diseases
Neurogenetics
Drosophila models